Metalloproteases and guidance of retinal axons in the developing visual system.

  title={Metalloproteases and guidance of retinal axons in the developing visual system.},
  author={Christine A. Webber and Jennifer C. Hocking and V. Wee Yong and Carrie L Stange and Rami Halabi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={22 18},
Axonal growth cones read cues in their environment that guide them to their target. Metalloproteases have been implicated in vitro in modulating the interaction of these cues with receptors in the growth cone. To determine whether metalloprotease function is important in the guidance of vertebrate axons in vivo, we applied hydroxamate-based metalloprotease inhibitors to Xenopus retinal ganglion cell (RGC) axons as they extended through the optic tract. In the presence of two different… CONTINUE READING


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