Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures

Interleukin-1 (IL-I) stimulates chondrocytes to increase the synthesis of metalloproteases, which can then degrade the cartilage extracellular matrix [1,2]. Growth factors, such as insulin-like growth factor-1 have been shown to decrease the catabolic effects of IL-1 [3]. Other studies have shown that compounds, such as synthetic matrix metalloprotease… CONTINUE READING