Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling.

@article{Eguchi2003MetalloproteasedependentEL,
  title={Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling.},
  author={Satoru Eguchi and Gerald Frank and Mizuo Mifune and Tadashi Inagami},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 Pt 6},
  pages={1198-202}
}
AngII (angiotensin II) and its G-protein-coupled AT(1) receptor play critical roles in mediating cardiovascular diseases such as hypertension, atherosclerosis and restenosis after vascular injury. It is widely believed that AngII promotes these diseases by inducing vascular remodelling that involves hypertrophy, hyperplasia and migration of VSMCs (vascular smooth muscle cells). We have shown that transactivation of an ErbB family receptor, EGFR (epidermal growth factor receptor; ErbB1), is… CONTINUE READING
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