Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast

  title={Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast},
  author={Philippa D Darbre},
  journal={Journal of Applied Toxicology},
  • P. Darbre
  • Published 1 May 2006
  • Chemistry, Medicine, Biology
  • Journal of Applied Toxicology
Many compounds in the environment have been shown capable of binding to cellular oestrogen receptors and then mimicking the actions of physiological oestrogens. The widespread origin and diversity in chemical structure of these environmental oestrogens is extensive but to date such compounds have been organic and in particular phenolic or carbon ring structures of varying structural complexity. Recent reports of the ability of certain metal ions to also bind to oestrogen receptors and to give… 

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Environmental oestrogens, cosmetics and breast cancer.

  • P. Darbre
  • Medicine, Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2006

Aluminium, antiperspirants and breast cancer.

  • P. Darbre
  • Medicine, Biology
    Journal of inorganic biochemistry
  • 2005

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Oestrogenic activity of parabens in MCF7 human breast cancer cells

Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens.

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Evaluation of estrogenicity of major heavy metals.

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