Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice.

@article{Xu2008MetalloelastaseIL,
  title={Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice.},
  author={Junyang Xu and Fang Xu and E S Barrett},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 1},
  pages={
          L162-70
        }
}
Metalloelastase (MMP-12), mainly produced by macrophages, has been shown to play a key role in the pathogenesis of emphysema in animal models. Chronic cigarette smoke increases pulmonary MMP-12, which is closely correlated with an elevation of pulmonary substance P (SP). Because alveolar macrophages (AMs) contain the neurokinin-1 receptor (NK1R), we tested whether SP was able to trigger the upregulation of MMP-12 synthesis in AMs by acting on the NK1R. AMs isolated from bronchoalveolar lavage… CONTINUE READING

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