Metallochaperones, an intracellular shuttle service for metal ions.

@article{OHalloran2000MetallochaperonesAI,
  title={Metallochaperones, an intracellular shuttle service for metal ions.},
  author={Thomas V. O'Halloran and Valeria C Culotta},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 33},
  pages={25057-60}
}
Enzymes that employ transition metals as co-factors are housed in a wide variety of intracellular locations or are exported to the extracellular milieu. A key question then arises: how are specific metal co-factors transported to diverse locations and subsequently sorted into the correct metalloenzymes? The mechanisms by which these tasks are accomplished are just now being unraveled. A new family of soluble metal receptor proteins known as “metallochaperones” is emerging that act in the… CONTINUE READING
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