Metallocarboxypeptidases and their inhibitors: recent developments in biomedically relevant protein and organic ligands.

Abstract

Metallocarboxypeptidases (MCPs) are zinc-dependent exoproteases that have been for long considered benchmark enzymes, perform a wide range of physiological roles and have been regarded as interesting drug targets. Several crystal structures of MCPs in complex with protein and small molecular weight inhibitors have recently been obtained providing a… (More)

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