Corpus ID: 39597009

Metallo-beta-lactamases: the quiet before the storm?

@article{Walsh2005MetallobetalactamasesTQ,
  title={Metallo-beta-lactamases: the quiet before the storm?},
  author={T. Walsh and M. Toleman and L. Poirel and P. Nordmann},
  journal={Clinical microbiology reviews},
  year={2005},
  volume={18 2},
  pages={
          306-25
        }
}
The ascendancy of metallo-beta-lactamases within the clinical sector, while not ubiquitous, has nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant Pseudomonas aeruginosa strains possess a metallo-beta-lactamase. Acquisition of a metallo-beta-lactamase gene will invariably mediate broad-spectrum beta-lactam resistance in P. aeruginosa, but the level of in vitro resistance in Acinetobacter spp. and Enterobacteriaceae is less dependable. Their clinical… Expand
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