Metallo-β-lactamases: structural features, antibiotic recognition, inhibition, and inhibitor design.

@article{Wang2013MetallolactamasesSF,
  title={Metallo-$\beta$-lactamases: structural features, antibiotic recognition, inhibition, and inhibitor design.},
  author={Jing-Fang Wang and K. Chou},
  journal={Current topics in medicinal chemistry},
  year={2013},
  volume={13 10},
  pages={
          1242-53
        }
}
Owing to their ability in destroying or slowing down the growth of bacteria, antibiotics have been widely used to treat the bacterial infections. However, because of the long-term and irresponsible use of antibiotics, resistance to antibiotics has become a serious problem directly threatening the public health worldwide. To fight against and resist β- lactam antibiotics, bacteria usually employed β-lactamases, especially the metallo-β-lactamases, to hydrolyze the C-N bond of the β-lactam ring… Expand
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