Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone.

  title={Metallo-$\beta$-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone.},
  author={Cassandra L. Retzlaff and Amanda K. Kussrow and Tim Schorkopf and Phoonthawee Saetear and Darryl J. Bornhop and J. Andrew Hardaway and Sarah M. Sturgeon and Jane Wright and Randy D. Blakely},
  journal={ACS chemical neuroscience},
  volume={8 10},
Ceftriaxone, a β-lactam antibiotic, has been reported to act independently of its antimicrobial actions to normalize perturbed central nervous system glutamate levels, principally by elevating expression of glial glutamate transporters. Identification of a specific, high-affinity target for ceftriaxone could significantly impact therapeutic development for multiple brain disorders, ranging from neurodegenerative disorders to addiction. Recently, we identified a glial-expressed Caenorhabditis… 
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