[Metallic trace elements--A1, Cd, Cu, Fe--in solutions of 111InCl3: determination by flameless atomic absorption and results in 111In-radiolabeling of monoclonal antibodies].

Abstract

Determination of trace elements in 111InCl3 solution have been carried out by flameless atomic absorption spectrometry. Five successive batches from three European companies have been analysed. The means of measured values range from 4560 to 6930 micrograms L-1 for aluminium, 131 to 874 for cadmium, 49 to 300 for copper, 387 to 698 for iron. Using two molar ration indexes, trivalent metallic traces have been compared to theoretical 111In content. The trace elements largely exceed radioactive material. As Fe and In have similar chemical properties, it results in low specific activity of radioactive complex when labeling monoclonal antibodies by 111In. Using a mathematical model, a detrimental effect of Fe trace levels has been studied.

Cite this paper

@article{Legendre1987MetallicTE, title={[Metallic trace elements--A1, Cd, Cu, Fe--in solutions of 111InCl3: determination by flameless atomic absorption and results in 111In-radiolabeling of monoclonal antibodies].}, author={Jean M Legendre and M. P. Moineau and Jean François Morin and Alexandre Turzo and Pascal Morin}, journal={International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes}, year={1987}, volume={38 9}, pages={751-6} }