Metal ions and oxidative protein modification in neurological disease.

  title={Metal ions and oxidative protein modification in neurological disease.},
  author={Lawrence M. Sayre and Paula I Moreira and Mark A. Smith and George Perry},
  journal={Annali dell'Istituto superiore di sanita},
  volume={41 2},
This review highlights the role of oxidative stress and imbalances in metal ion homeostasis in the neurodegenerative diseases Alzheimer's disease and Parkinson's disease and in the progressive demyelinating disease multiple sclerosis. The chemistry and biochemistry of oxidative stress-induced protein damage are first described, followed by the evidence for a pathological role of oxidative stress in these disease states. It is tempting to speculate that free radical oxygen chemistry contributes… CONTINUE READING
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