Metal ion sensors based on DNAzymes and related DNA molecules.

  title={Metal ion sensors based on DNAzymes and related DNA molecules.},
  author={Xiaobing Zhang and Rong-Mei Kong and Yi Lu},
  journal={Annual review of analytical chemistry},
Metal ion sensors are an important yet challenging field in analytical chemistry. Despite much effort, only a limited number of metal ion sensors are available for practical use because sensor design is often a trial-and-error-dependent process. DNAzyme-based sensors, in contrast, can be developed through a systematic selection that is generalizable for a wide range of metal ions. Here, we summarize recent progress in the design of DNAzyme-based fluorescent, colorimetric, and electrochemical… CONTINUE READING
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The Ca2+ion as a cofactor for a novel RNA-cleaving deoxyribozyme

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