Metal ion and ligand binding of integrin α5β1.

@article{Xia2014MetalIA,
  title={Metal ion and ligand binding of integrin α5β1.},
  author={Wei Xia and Timothy A Springer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 50},
  pages={17863-8}
}
Integrin α5β1 binds to an Arg-Gly-Asp (RGD) motif in its ligand fibronectin. We report high-resolution crystal structures of a four-domain α5β1 headpiece fragment, alone or with RGD peptides soaked into crystals, and RGD peptide affinity measurements. The headpiece crystallizes in a closed conformation essentially identical to that seen previously for α5β1 complexed with a Fab that allosterically inhibits ligand binding by stabilizing the closed conformation. Soaking experiments show that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…