Metal-histidine-glutamate as a regulator of enzymatic cycles: a case study of carbonic anhydrasew

Abstract

Histidine is a very common metal ligand in metalloenzymes. Besides being an efficient Lewis base, its electronic properties are essential to shape the metal ability to catalyze the reaction. Here we show that histidine’s properties can be tuned, in turn, by an easy proton transfer to a nearby glutamate. We study this situation in Human Carbonic Anhydrase II… (More)

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Cite this paper

@inproceedings{Frison2008MetalhistidineglutamateAA, title={Metal-histidine-glutamate as a regulator of enzymatic cycles: a case study of carbonic anhydrasew}, author={Gilles Frison and Gilles Ohanessian}, year={2008} }