Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.

@article{Hayne2014MetalCD,
  title={Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.},
  author={David J. Hayne and Sinchun Lim and Paul S Donnelly},
  journal={Chemical Society reviews},
  year={2014},
  volume={43 19},
  pages={
          6701-15
        }
}
Alzheimer's disease is the most common form of age-related neurodegenerative dementia. The disease is characterised by the presence of plaques in the cerebral cortex. The major constituent of these plaques is aggregated amyloid-β peptide. This review focuses on the molecular aspects of metal complexes designed to bind to amyloid-β. The development of radioactive metal-based complexes of copper and technetium designed as diagnostic imaging agents to detect amyloid burden in the brain is… CONTINUE READING

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