Metal complex-DNA interactions: from transcription inhibition to photoactivated cleavage.

@article{Boerner2005MetalCI,
  title={Metal complex-DNA interactions: from transcription inhibition to photoactivated cleavage.},
  author={Leigh J K Boerner and Jeffrey M. Zaleski},
  journal={Current opinion in chemical biology},
  year={2005},
  volume={9 2},
  pages={135-44}
}
Metal ions and complexes, because of their cationic character, three-dimensional structural profiles, and propensity for performing hydrolysis, redox, or photoreactions, have a natural aptitude for interacting with DNA. Indeed, the need for cellular regulation of DNA led to the evolution of metallonucleases to catalyze and repair DNA strand breaks. Moreover, inorganic constructs such as cisplatin and bimetallic rhodium acetate exert antitumor activity by inner-sphere coordination to DNA… CONTINUE READING
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