Metal chelator combined with permeability enhancer ameliorates oxidative stress-associated neurodegeneration in rat eyes with elevated intraocular pressure.

@article{Liu2014MetalCC,
  title={Metal chelator combined with permeability enhancer ameliorates oxidative stress-associated neurodegeneration in rat eyes with elevated intraocular pressure.},
  author={Ping Liu and Min Zhang and Mohammad Shoeb and Dale Hogan and Luosheng Tang and Misha F. Syed and Cheng Zhang Wang and Gerald A. Campbell and Naseem Hasan Ansari},
  journal={Free radical biology & medicine},
  year={2014},
  volume={69},
  pages={289-99}
}
Because as many as half of glaucoma patients on intraocular pressure (IOP)-lowering therapy continue to experience optic nerve toxicity, it is imperative to find other effective therapies. Iron and calcium ions play key roles in oxidative stress, a hallmark of glaucoma. Therefore, we tested metal chelation by means of ethylenediaminetetraacetic acid (EDTA) combined with the permeability enhancer methylsulfonylmethane (MSM) applied topically on the eye to determine if this noninvasive treatment… CONTINUE READING