Metal-based inhibitors of protein tyrosine phosphatases.

@article{Lu2011MetalbasedIO,
  title={Metal-based inhibitors of protein tyrosine phosphatases.},
  author={Liping Lu and Miaoli Zhu},
  journal={Anti-cancer agents in medicinal chemistry},
  year={2011},
  volume={11 1},
  pages={164-71}
}
Protein tyrosine phosphatases (PTPs) are a large family of signaling enzymes playing critical role in signal transduction and regulation of cellular processes. Dysfunction of PTP activity is associated with diabetes, cancer, autoimmune disorders, and neural diseases. PTP inhibitors therefore emerged as promising therapeutic targets. Recent research… CONTINUE READING