Metal-Sulfate Induced Generation of ROS in Human Brain Cells: Detection Using an Isomeric Mixture of 5- and 6-Carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a Cell Permeant Tracer

@inproceedings{Pogue2012MetalSulfateIG,
  title={Metal-Sulfate Induced Generation of ROS in Human Brain Cells: Detection Using an Isomeric Mixture of 5- and 6-Carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a Cell Permeant Tracer},
  author={Aileen I. D. Pogue and Brandon M. Jones and Surjyadipta Bhattacharjee and Maire E. Percy and Walter J. Lukiw},
  booktitle={International journal of molecular sciences},
  year={2012}
}
Evolution of reactive oxygen species (ROS), generated during the patho-physiological stress of nervous tissue, has been implicated in the etiology of several progressive human neurological disorders including Alzheimer's disease (AD) and amylotrophic lateral sclerosis (ALS). In this brief communication we used mixed isomers of 5-(and-6)-carboxy-2',7'-dichlorofluorescein diacetate (carboxy-DCFDA; C(25)H(14)C(l2)O(9); MW 529.3), a novel fluorescent indicator, to assess ROS generation within human… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells

P. N. Alexandrov, Y. Zhao, +5 authors W. J. Lukiw
  • J. Alzheimers Dis. 2005,
  • 2005
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Houston, TX, USA, 2005

Aluminum Sulfate, MSDS Number 76324, Inc. Sciencelab.com
  • Available online: http://www.sciencelab.com/msds.php?msdsId=9922864
  • 2012

Redox proteomics.

  • Antioxidants & redox signaling
  • 2012
VIEW 2 EXCERPTS