Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.

  title={Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.},
  author={Aditi R Deshpande and Karina Wagenpfeil and Thomas C Pochapsky and Gregory A. Petsko and Dagmar Ringe},
  volume={55 9},
The two acireductone dioxygenase (ARD) isozymes from the methionine salvage pathway of Klebsiella oxytoca are the only known pair of naturally occurring metalloenzymes with distinct chemical and physical properties determined solely by the identity of the divalent transition metal ion (Fe(2+) or Ni(2+)) in the active site. We now show that this dual… CONTINUE READING