Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic.

@article{Gambino2019MetalCI,
  title={Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic.},
  author={Dinorah Gambino and Luc{\'i}a Otero {\'A}},
  journal={Metal ions in life sciences},
  year={2019},
  volume={19}
}
Metal compounds seem to be a promising approach in the search of new therapeutic solutions for neglected tropical diseases. In this chapter, efforts in the design of prospective metal-based drugs for the treatment of Chagas disease, human African trypanosomiasis, and leishmaniasis are discussed. Careful selection of the metal center (including organometallic cores) and the types and number of coordinated ligands is essential for controlling the reactivity of the complexes and hence, tuning… 
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References

Multi-target heteroleptic palladium bisphosphonate complexes
TLDR
Four new palladium heteroleptic complexes with N -containing commercial bisphosphonates and DNA intercalating polypyridyl co-ligands were synthesized and fully characterized and displayed high anti- T. cruzi activity which could be related to the inhibition of the parasitic farnesyl diphosphate synthase enzyme but mainly to their ability to interact DNA.