Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

@article{Polvi2016MetalCA,
  title={Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis},
  author={Elizabeth J. Polvi and Anna Floyd Averette and Soo Chan Lee and Taeyup Kim and Yong-Sun Bahn and Amanda O. Veri and Nicole Robbins and Joseph Heitman and Leah E. Cowen},
  journal={PLoS Genetics},
  year={2016},
  volume={12}
}
Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance. Defining circuitry controlling these traits opens new opportunities for chemical diversity in therapeutics, as the cognate inhibitors are rarely explored by conventional screening approaches. This has great potential to address the pressing need for new therapeutic strategies for invasive fungal infections, which have a staggering impact on… 
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