Metal-Catalyzed Azidation of Tertiary C–H Bonds Suitable for Late-Stage Functionalization

@inproceedings{Sharma2015MetalCatalyzedAO,
  title={Metal-Catalyzed Azidation of Tertiary C–H Bonds Suitable for Late-Stage Functionalization},
  author={Ankit Sharma and John F Hartwig},
  booktitle={Nature},
  year={2015}
}
Many enzymes oxidize unactivated aliphatic C–H bonds selectively to form alcohols; however, biological systems do not possess enzymes that catalyse the analogous aminations of C–H bonds. The absence of such enzymes limits the discovery of potential medicinal candidates because nitrogen-containing groups are crucial to the biological activity of therapeutic agents and clinically useful natural products. In one prominent example illustrating the importance of incorporating nitrogen-based… CONTINUE READING

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