Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells

@article{Iniguez2013MetaldrugSN,
  title={Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells},
  author={Eva A Iniguez and Antonio Concha Sanchez and Miguel A. Vasquez and Alberto Mart{\'i}nez and J. Blanquer Olivas and Aaron Sattler and Roberto A. S{\'a}nchez-Delgado and Rosa A Maldonado},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2013},
  volume={18},
  pages={779-790}
}
In our ongoing search for new metal-based chemotherapeutic agents against leishmaniasis and Chagas disease, six new ruthenium–ketoconazole (KTZ) complexes have been synthesized and characterized, including two octahedral coordination complexes—cis,fac-[RuIICl2(DMSO)3(KTZ)] (1) and cis-[RuIICl2(bipy)(DMSO)(KTZ)] (2) (where DMSO is dimethyl sulfoxide and bipy is 2,2′-bipyridine)—and four organometallic compounds—[RuII(η6-p-cymene)Cl2(KTZ)] (3), [RuII(η6-p-cymene)(en)(KTZ)][BF4]2 (4), [RuII(η6-p… CONTINUE READING