# Metal‐Induced Alterations of δ‐Aminolevulinic Acid Dehydratase

@article{Bernard1987MetalInducedAO,
title={Metal‐Induced Alterations of $\delta$‐Aminolevulinic Acid Dehydratase},
author={A. Bernard and Robert Lauwerys},
journal={Annals of the New York Academy of Sciences},
year={1987},
volume={514}
}
• Published 1 December 1987
• Chemistry, Medicine
• Annals of the New York Academy of Sciences
ALAD is a cytoplasmic enzyme that catalyzes the second step of the heme biosynthesis pathway, that is, the condensation of two molecules of delta-aminolevulinic acid into porphobilinogen. ALAD is a zinc-dependent enzyme; thiol groups are essential for its activity; and in vitro experiments show that ALAD can be activated or inhibited by several metal ions including A;3+, Pb2+, Cd2+, Hg2+, Ag2+, and Cu2+. To explain these effects, it has been postulated that metals bind to thiol groups of… Expand
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