Metal‐Free Triazole Formation as a Tool for Bioconjugation

  title={Metal‐Free Triazole Formation as a Tool for Bioconjugation},
  author={S. van Berkel and A Ton J Dirks and Marjoke F. Debets and Floris L. van Delft and Jeroen J. L. M. Cornelissen and Roeland J. M. Nolte and F.P.J.T. Rutjes},
The development of selective and site-specific bio-orthogonal conjugation methods is an important topic in chemical biology. A wide range of methods, such as the Staudinger ligation, native chemical ligation, genetic incorporation, expressed-protein ligation, Huisgen azide–alkyne cycloaddition, and the Diels–Alder ligation are currently employed in the selective modification of proteins and other biomolecules. In recent years, the Cu-catalyzed variant of the Huisgen 1,3-dipolar cycloaddition… 

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  • Manuel GregoritzaF. Brandl
  • Biology, Chemistry
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2015

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