Metagenomics to paleogenomics: large-scale sequencing of mammoth DNA.

  title={Metagenomics to paleogenomics: large-scale sequencing of mammoth DNA.},
  author={Hendrik N Poinar and Carsten Schwarz and Ji Qi and Beth Shapiro and Ross D E MacPhee and Bernard Buigues and A. Yu. Tikhonov and Daniel H. Huson and Lynn P. Tomsho and Alexander Auch and Markus Rampp and Webb Miller and Stephan C. Schuster},
  volume={311 5759},
We sequenced 28 million base pairs of DNA in a metagenomics approach, using a woolly mammoth (Mammuthus primigenius) sample from Siberia. As a result of exceptional sample preservation and the use of a recently developed emulsion polymerase chain reaction and pyrosequencing technique, 13 million base pairs (45.4%) of the sequencing reads were identified as mammoth DNA. Sequence identity between our data and African elephant (Loxodonta africana) was 98.55%, consistent with a paleontologically… CONTINUE READING
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