Metagenomic systems biology and metabolic modeling of the human microbiome
@article{Levy2014MetagenomicSB, title={Metagenomic systems biology and metabolic modeling of the human microbiome}, author={Roie Levy and Elhanan Borenstein}, journal={Gut Microbes}, year={2014}, volume={5}, pages={265 - 270 - 9} }
The human microbiome is a key contributor to health and development. Yet little is known about the ecological forces that are at play in defining the composition of such host-associated communities. Metagenomics-based studies have uncovered clear patterns of community structure but are often incapable of distinguishing alternative structuring paradigms. In a recent study, we integrated metagenomic analysis with a systems biology approach, using a reverse ecology framework to model numerous…
38 Citations
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Mapping the InnerWorkings of theMicrobiome : Genomic-andMetagenomic-BasedStudyofMetabolism andMetabolic Interactions in the HumanMicrobiome
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Two interrelated lines of work are highlighted, the first aiming to deconvolve the microbiome and to characterize the metabolic capacity of various microbiome species and the second aiming to utilize computational modeling to infer and study metabolic interactions between these species.
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