Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses.

@article{Kampa2013MetagenomicNP,
  title={Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses.},
  author={Annette Kampa and Andrey N. Gagunashvili and Tobias A. M. Gulder and Brandon I Morinaka and Cristina Daolio and Markus Godejohann and Vivian P. W. Miao and J{\"o}rn Piel and {\'O}lafur S Andr{\'e}sson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 33},
  pages={
          E3129-37
        }
}
Bacteria are a major source of natural products that provide rich opportunities for both chemical and biological investigation. Although the vast majority of known bacterial metabolites derive from free-living organisms, increasing evidence supports the widespread existence of chemically prolific bacteria living in symbioses. A strategy based on bioinformatic prediction, symbiont cultivation, isotopic enrichment, and advanced analytics was used to characterize a unique polyketide, nosperin… CONTINUE READING

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