Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta.

@article{Schirmer2005MetagenomicAR,
  title={Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta.},
  author={Andreas Schirmer and Rishali Gadkari and Christopher D. Reeves and Fadia Ibrahim and Edward F DeLong and Charles R. Hutchinson},
  journal={Applied and environmental microbiology},
  year={2005},
  volume={71 8},
  pages={
          4840-9
        }
}
Sponge-associated bacteria are thought to produce many novel bioactive compounds, including polyketides. PCR amplification of ketosynthase domains of type I modular polyketide synthases (PKS) from the microbial community of the marine sponge Discodermia dissoluta revealed great diversity and a novel group of sponge-specific PKS ketosynthase domains. Metagenomic libraries totaling more than four gigabases of bacterial genomes associated with this sponge were screened for type I modular PKS gene… CONTINUE READING
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