Metagenomic Analysis of Nitrate-Reducing Bacteria in the Oral Cavity: Implications for Nitric Oxide Homeostasis

  title={Metagenomic Analysis of Nitrate-Reducing Bacteria in the Oral Cavity: Implications for Nitric Oxide Homeostasis},
  author={Embriette R. Hyde and F. Andrade and Zalman Vaksman and K. Parthasarathy and H. Jiang and Deepa K. Parthasarathy and Ashley C. Torregrossa and G. Tribble and H. Kaplan and J. Petrosino and N. Bryan},
  journal={PLoS ONE},
  • Embriette R. Hyde, F. Andrade, +8 authors N. Bryan
  • Published 2014
  • Biology, Medicine
  • PLoS ONE
  • The microbiota of the human lower intestinal tract helps maintain healthy host physiology, for example through nutrient acquisition and bile acid recycling, but specific positive contributions of the oral microbiota to host health are not well established. [...] Key Result We identified 14 candidate species, seven of which were not previously believed to contribute to nitrate reduction.Expand Abstract
    Characterization of the rat oral microbiome and the effects of dietary nitrate.
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    Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans
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    Salivary nitrite production is elevated in individuals with a higher abundance of oral nitrate‐reducing bacteria
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    From Nitrate to Nitric Oxide
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    The influence of the human microbiome and probiotics on cardiovascular health
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    Nitrate, the oral microbiome, and cardiovascular health: a systematic literature review of human and animal studies.
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