Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

  title={Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.},
  author={Alain Doucet and Georgina S. Butler and David Rodríguez and Anna Prudova and Christopher M. Overall},
  journal={Molecular \& cellular proteomics : MCP},
  volume={7 10},
Post-translational modifications enable extra layers of control of the proteome, and perhaps the most important is proteolysis, a major irreversible modification affecting every protein. The intersection of the protease web with a proteome sculpts that proteome, dynamically modifying its state and function. Protease expression is distorted in cancer, so perturbing signaling pathways and the secretome of the tumor and reactive stromal cells. Indeed many cancer biomarkers are stable proteolytic… 

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