Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

@article{Doucet2008MetadegradomicsTI,
  title={Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.},
  author={Alain Doucet and Georgina S. Butler and David Rodriguez and Anna Prudova and Christopher M. Overall},
  journal={Molecular & cellular proteomics : MCP},
  year={2008},
  volume={7 10},
  pages={1925-51}
}
Post-translational modifications enable extra layers of control of the proteome, and perhaps the most important is proteolysis, a major irreversible modification affecting every protein. The intersection of the protease web with a proteome sculpts that proteome, dynamically modifying its state and function. Protease expression is distorted in cancer, so perturbing signaling pathways and the secretome of the tumor and reactive stromal cells. Indeed many cancer biomarkers are stable proteolytic… CONTINUE READING
51 Citations
213 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 213 references

Protease degrado- mics: mass spectrometry discovery of protease substrates and the Quantitative Degradomics of the Cancer Proteome

  • C. M. Overall, E. M. Tam, +6 authors A. Seth
  • Biol. Chem
  • 2004
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…