Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling.

@article{Martn2011MetabotypingOC,
  title={Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling.},
  author={F. de Juan Mart{\'i}n and Britta Spanier and Sebastiano Collino and Ivan Montoliu and Carolin Adriane Kolmeder and Pieter Giesbertz and Michael Affolter and Martin Kussmann and Hannelore Daniel and Sunil Kochhar and Serge Rezzi},
  journal={Journal of proteome research},
  year={2011},
  volume={10 3},
  pages={990-1003}
}
Insulin/IGF-like signaling (IIS) and nutrient sensing are among the most potent regulators of health status and aging. Here, a global view of the metabolic changes in C. elegans with impaired function of IIS represented by daf-2 and daf-16 and the intestinal di- and tripeptide transport pept-1 was generated using (1)H nuclear magnetic resonance spectroscopic analysis of worm extracts and spent culture media. We showed that specific metabolic profiles were significantly associated with each type… CONTINUE READING

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