Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons.


BACKGROUND AND AIMS Inhibitory G-protein-coupled receptors have demonstrated potential in treatment of gastroesophageal reflux disease (GERD) through actions on vagal afferent signaling. Metabotropic glutamate receptors (mGluR) belong to this receptor family and have great pharmacologic and molecular diversity, with 8 subtypes. We investigated mGluR in the… (More)


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