Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation.

@article{Montana2011MetabotropicGR,
  title={Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation.},
  author={Michael C. Montana and Robert W Gereau},
  journal={Current pharmaceutical biotechnology},
  year={2011},
  volume={12 10},
  pages={1681-8}
}
The metabotropic glutamate receptors (mGluRs) are expressed pre- and post-synaptically throughout the nervous system where they serve as modulators of synaptic transmission and neuronal excitability. Activation of mGluRs can be pro- or anti-nociceptive, depending on their anatomic location and the signaling cascades to which they couple. Antagonists of Group I mGluRs and agonists of Group II and III mGluRs have shown therapeutic promise in animal pain models. This article reviews the potential… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

mGlu5 negative allosteric modulators: a patent review (2013 - 2016).

Expert opinion on therapeutic patents • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…