Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

@article{Swanson2005MetabotropicGR,
  title={Metabotropic glutamate receptors as novel targets for anxiety and stress disorders},
  author={Chad J. Swanson and Mark Bures and Michael P. Johnson and A M Lind{\'e}n and James A. Monn and Darryle D. Schoepp},
  journal={Nature Reviews Drug Discovery},
  year={2005},
  volume={4},
  pages={131-144}
}
Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and current treatments are less than satisfactory. So, the discovery of novel approaches to treat anxiety disorders remains an important area of neuroscience research. Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system, and G-protein-coupled metabotropic glutamate (mGlu) receptors function to regulate excitability via pre- and postsynaptic mechanisms. Various mGlu… CONTINUE READING