Metabotropic glutamate receptors: physiology, pharmacology, and disease.


The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals through the receptor protein to intracellular signaling partners… (More)
DOI: 10.1146/annurev.pharmtox.011008.145533