Metabotropic glutamate receptor-mediated excitation and inhibition of sympathetic preganglionic neurones.

@article{Nolan1998MetabotropicGR,
  title={Metabotropic glutamate receptor-mediated excitation and inhibition of sympathetic preganglionic neurones.},
  author={Matthew F. Nolan and Sanjay Logan},
  journal={Neuropharmacology},
  year={1998},
  volume={37 1},
  pages={13-24}
}
The effects of metabotropic glutamate receptor (mGluR) subtype selective compounds on the excitability of sympathetic preganglionic neurones (SPNs) were investigated. Non-selective mGluR agonists (1S,3R)-aminocyclopentane-1,3-dicarboxylic acid and (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine, induced dose-dependent depolarisations in 96 and 75% of SPNs, respectively and hyperpolarisations in 2 and 21% of SPNs. Both agonists could induce subthreshold membrane potential oscillations in previously… CONTINUE READING