Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response.

Abstract

Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of nearby arterioles. Using concurrent in vivo optical imaging and determination of receptor occupancy with (11)C-ABP688, we… (More)
DOI: 10.1038/jcbfm.2011.96

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