Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs.

@article{Palucha2007MetabotropicGR,
  title={Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs.},
  author={Agnieszka Palucha and Andrzej Pilc},
  journal={Pharmacology & therapeutics},
  year={2007},
  volume={115 1},
  pages={116-47}
}
Depression and anxiety represent a major problem. However, the current treatment of both groups of diseases is not satisfactory. As the glutamatergic system may play an important role in pathophysiology of both depression and anxiety, we decided to discuss the recent data on possible anxiolytic and/or antidepressant effects of metabotropic glutamate (mGlu) receptor ligands. Preclinical data indicated that antagonists of group I mGlu receptors, particularly antagonists of mGlu5 receptors… CONTINUE READING

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