Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics.

@article{Varney2002MetabotropicGR,
  title={Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics.},
  author={Mark A. Varney and Robert W Gereau},
  journal={Current drug targets. CNS and neurological disorders},
  year={2002},
  volume={1 3},
  pages={283-96}
}
The excitatory amino acid glutamate plays a major role in nociceptive processing. Ionotropic and metabotropic glutamate receptors are expressed in relevant areas of the brain, spinal cord and periphery that are involved in pain sensation and transmission. Activation of mGlu receptors along the pain neuraxis can result in either pronociceptive or antinociceptive behaviors depending on the subtype of mGluR and its location. The data published to date most strongly support the idea that mGlu1… CONTINUE READING

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