Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust.

  title={Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust.},
  author={Jocelyn M Richard and Kent C. Berridge},
  journal={The European journal of neuroscience},
  volume={33 4},
Glutamatergic inputs to the nucleus accumbens (NAc) modulate both appetitive and fearful motivation. It has been suggested that pathological disturbances of glutamate signaling in NAc contribute to motivation disorders, ranging from excessive desire in drug addiction to paranoia in schizophrenia. Metabotropic glutamate receptors are of special interest, as metabotropic Group II receptor (mglu2/3) agonists have been proposed as potential treatments for both addiction and schizophrenia. Here we… CONTINUE READING


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