Metabotropic glutamate receptor antagonist, (R,S)-α-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus

@article{Little1995MetabotropicGR,
  title={Metabotropic glutamate receptor antagonist, (R,S)-$\alpha$-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus},
  author={Zeb Little and Lawrence M. Grover and Timothy James Teyler},
  journal={Neuroscience Letters},
  year={1995},
  volume={201},
  pages={73-76}
}
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42 Citations
Highly Influential Citations
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42 Citations

The role of group II metabotropic glutamate receptors in hippocampal CA1 long-term potentiation in vitro.
Contributions of AMPA and GABAA receptors to the induction of NMDAR-dependent LTP in CA1
Subtype-specific involvement of metabotropic glutamate receptors in two forms of long-term potentiation in the dentate gyrus of freely moving rats
Evidence for involvement of group II/III metabotropic glutamate receptors in NMDA receptor-independent long-term potentiation in area CA1 of rat hippocampus.
TLDR
It is suggested that group II mGluRs are required for induction of NMDA receptor-independent LTP, and that group III mGLURs are involved in determining the input specificity of NMda receptor- independent LTP by suppressing potentiation of nearby, nontetanized synapses.
Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors.
TLDR
The results indicate that caution should be used when using these drugs to study the roles of mGluRs in various NMDA-dependent processes, and several of the drugs also act as agonists at higher concentrations due at least in part to high levels of contaminant amino acids.
When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?
TLDR
The functional significance of class I mGluRs in LTP is confined to certain types of potentiation, which are induced by weak tetanization protocols and require the release of Ca2+ from ICSs for induction.
Arachidonic acid rescues hippocampal long-term potentiation blocked by group I metabotropic glutamate receptor antagonists
Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons.
1-Aminocyclopentane-trans-1,3-dicarboxylic acid, an agonist of the metabotropic glutamate receptors 1, 2, 3 and 5, prevents neurotoxicity of glutamate and of N-methyl-D-aspartate in primary cultures…
PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro.
An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro
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References

SHOWING 1-10 OF 43 REFERENCES
(RS)-α-Methyl-4-carboxyphenylglycine (MCPG) does not block theta burst-induced long-term potentiation in area CA1 of rat hippocampal slices
(R,S)-α-Methyl-4-carboxyphenylglycine (MCPG) blocks spatial learning in rats and long-term potentiation in the dentate gyrus in vivo
(RS)-alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons.
TLDR
Observations suggest that MCPG is not an antagonist of the subtypes of mGlu receptors that are present in CA1 pyramidal neuron.
Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices
Co-activation of metabotropic glutamate and N-methyl-d-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal ca1 neurons
The role of N-methyl-d-aspartate receptors in the generation of short-term potentiation in the rat hippocampus
2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices
Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors
TLDR
(RS)-α-methyl-4-carboxyphenylglycine is a specific mGluR antagonist in the hippocampus and this compound is used to examine the nature of the involvement ofmGluRs in LTP, and it is shown that synaptic activation of mGLURs is necessary for the induction of both NMDA receptor-dependent and NMDA receptors-independent forms of LTP inThe hippocampus.
N-methyl-d-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: Input-specific induction and preclusion in a non-tetanized pathway
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