Metabotropic glutamate receptor antagonist, (R,S)-α-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus

  title={Metabotropic glutamate receptor antagonist, (R,S)-$\alpha$-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus},
  author={Zeb Little and Lawrence M. Grover and Timothy James Teyler},
  journal={Neuroscience Letters},
Evidence for involvement of group II/III metabotropic glutamate receptors in NMDA receptor-independent long-term potentiation in area CA1 of rat hippocampus.
It is suggested that group II mGluRs are required for induction of NMDA receptor-independent LTP, and that group III mGLURs are involved in determining the input specificity of NMda receptor- independent LTP by suppressing potentiation of nearby, nontetanized synapses.
Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors.
The results indicate that caution should be used when using these drugs to study the roles of mGluRs in various NMDA-dependent processes, and several of the drugs also act as agonists at higher concentrations due at least in part to high levels of contaminant amino acids.
When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?
The functional significance of class I mGluRs in LTP is confined to certain types of potentiation, which are induced by weak tetanization protocols and require the release of Ca2+ from ICSs for induction.
Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons.
1-Aminocyclopentane-trans-1,3-dicarboxylic acid, an agonist of the metabotropic glutamate receptors 1, 2, 3 and 5, prevents neurotoxicity of glutamate and of N-methyl-D-aspartate in primary cultures


(RS)-alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons.
Observations suggest that MCPG is not an antagonist of the subtypes of mGlu receptors that are present in CA1 pyramidal neuron.
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors
(RS)-α-methyl-4-carboxyphenylglycine is a specific mGluR antagonist in the hippocampus and this compound is used to examine the nature of the involvement ofmGluRs in LTP, and it is shown that synaptic activation of mGLURs is necessary for the induction of both NMDA receptor-dependent and NMDA receptors-independent forms of LTP inThe hippocampus.