Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes.

@article{Sureda1997MetabotropicGR,
  title={Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes.},
  author={Francesc X Sureda and Agata G. Copani and Valeria Bruno and Thomas Kn{\"o}pfel and G Meltzger and Ferdinando Nicoletti},
  journal={European journal of pharmacology},
  year={1997},
  volume={338 2},
  pages={R1-2}
}
The metabotropic glutamate (mGlu) receptor agonists, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), but not (RS)-3,5-dihydroxyphenylglycine or (2S,3S,4S)-alpha-(carboxycyclopropyl)glycine, stimulated [3H]inositolmonophosphate ([3H]InsP) formation in primary cultures of rat hepatocytes. 1S,3R-ACPD-stimulated [3H]InsP formation was inhibited by alpha-methyl-4-carboxyphenylglycine, indicating that cultured hepatocytes express functional mGlu receptors coupled to… CONTINUE READING

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