Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic–pituitary–adrenal axis activity: interaction with serotonergic systems

@article{Bradbury2003MetabotropicGR,
  title={Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic–pituitary–adrenal axis activity: interaction with serotonergic systems},
  author={Margaret J. Bradbury and Darlene R Giracello and Deborah F Chapman and Greg Holtz and Herv{\'e} J. Schaffhauser and S. Panduranga Rao and Mark A. Varney and Jeffery J Anderson},
  journal={Neuropharmacology},
  year={2003},
  volume={44},
  pages={562-572}
}
The mGluR5 antagonist 2-methyl-6-(phenylethynyl) pyridine (MPEP) produces anxiolytic or antidepressant effects in several rodent models through incompletely described mechanisms. Anxiolytics and antidepressants share several neuroendocrine features, including acute activation of the hypothalamic-pituitary-adrenal (HPA)-axis, desensitization of neuroendocrine responses with repeated dosing, and desensitization of the HPA axis to 5-HT1A agonist stimulation. We characterized these neuroendocrine… CONTINUE READING

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