Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

@article{Pisani2001MetabotropicGR,
  title={Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.},
  author={Antonio Pisani and Paolo Gubellini and Paola Bonsi and François Conquet and Barbara Picconi and Diego Centonze and Giorgio Bernardi and Paolo Calabresi},
  journal={Neuroscience},
  year={2001},
  volume={106 3},
  pages={579-87}
}
Medium spiny neurons were recorded from striatal slices obtained from mice lacking the group I metabotropic glutamate receptor (mGluR) subtype 1 or subtype 5. In wild-type animals, N-methyl-D-aspartate (NMDA)-induced membrane depolarization/inward currents were potentiated in the presence of both the group I mGluR agonist 3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 selective agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG). Likewise, in mGluR1 knockout mice, both 3,5-DHPG and CHPG… CONTINUE READING
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