Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome.

  title={Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome.},
  author={Sebastian Scharf and Georg Jaeschke and Joseph G. Wettstein and Lothar Lindemann},
  journal={Current opinion in pharmacology},
Fragile X syndrome (FXS) is the most common monogenic form of inherited mental retardation caused by a trinucleotid repeat expansion and transcriptional shutdown of the FMR1 gene. FXS patients present a complex and often severe neuropsychiatric phenotype yet have mild somatic symptoms, normal life expectancies, and no indications of neurodegeneration. The therapeutic potential of mGlu5 inhibitors was proposed in the 'mGluR theory of FXS' based on early insights into the molecular… CONTINUE READING
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