Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking.

@article{Kumaresan2009MetabotropicGR,
  title={Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking.},
  author={V. Kumaresan and Menglu Yuan and Judy Yee and Katie R Famous and Sharon M. Anderson and Heath D Schmidt and R. Christopher Pierce},
  journal={Behavioural brain research},
  year={2009},
  volume={202 2},
  pages={238-44}
}
Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior. In the present experiments, rats were trained to self-administer cocaine under fixed ratio (for cocaine priming-induced reinstatement) or second-order (for cocaine cue-induced reinstatement) schedules of reinforcement. Lever pressing was then extinguished followed by a reinstatement phase where operant responding was promoted… CONTINUE READING

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